Prof. Hongtao LEI
Professor
College of Food Science, South China Agricultural University
Email: hongtao@scau.edu.cn
Biography
Dr. Lei Hongtao, a second-level professor and doctoral supervisor, has been honored as the Young Innovation Leader of the National High-level Talent Special Support Program, the Young Science and Technology Innovation Leader of the National Innovation Talent Promotion Program, and the Science and Technology Innovation Leader of the Guangdong Special Support Program. He also serves as the Deputy Chairman of the Food Science and Engineering Teaching Steering Committee of higher Education institutions under the Ministry of Education. Additionally, he is a member of the National Food and Nutrition Graduate Education Steering Committee, Vice Chairman of the Agricultural Product Processing and Storage Engineering Committee of Chinese Society of Agricultural Engineering, Vice Chairman of Guangdong Food Society, Chief Scientist for agricultural product quality and safety common key technology innovation team in Guangdong modern agricultural industry system.
Research Interests
Food safety, nutrition and Health
Teaching
Immunoassay Technology, Food Nutrition, Food Analysis
Selected Publications
1、Lin Ye, Huodai Chen, Karl Wah Keung Tsim, Xing Shen, Xiangmei Li, Xueling Li, Hongtao Lei*, Yunle Liu*. Aflatoxin B1 Induces Inflammatory Liver Injury via Gut Microbiota in Mice.Journal of Agriculture and Food Chemistry. 2023, 71(28): 10787–10797.
2、Yunle Liu, Lin Ye, Huodai Chen, Karl Wah Keung Tsim, Xing Shen, Xiangmei Li, Xueling Li, Hongtao Lei*. Herbicide propisochlor exposure induces intestinal barrier impairment, microbiota dysbiosis and gut pyroptosis. 2023. Ecotoxicology and Environmental Safety. 262, 115154–115164
3、 Qiqi Quan, Zhiwei Liu, Zhaodong Li, Kangliang Pan, Anastasios Koidis, Anastasios Koidis, Yi Lei, Xiaoqin Yu, Qiuhua Mo, Xinan Huang, Hongtao Lei*. Authenticating Emergent Adulterant 6-Benzylaminopurine in Bean Sprouts: Virtual Hapten Similarity Enhanced Immunoassay. 2023. Journal of Agricultural and Food Chemistry. 71(21): 8203–8210
4、 Kangliang Pan, Zhiwei Liu, Zhaodong Li, Mindan Chen, Qiqi Quan, Xiaoqin Yu, Yi Lei, Qiuhua Mo, Bingzhi Wang, Tian Guan*, Hongtao Lei*.Identifying fungicide difenoconazole as illegal growth regulator in vegetable: computer-aided hapten similarity to enhance sensitivity of immunoassay. 2023. Analytica Chimica Acta, 1258: 341182 - 341189
5、Yalin Fang#, Zian Wang#, Qiqi Quan, Zhaodong Li, Kangliang Pan, Yi Lei, Xiaojun Yao, Xiangmei Li, Xing Shen, Anastasios Koidis*, Hongtao Lei*. Developing an ultrasensitive immunochromatographic assay for authentication of an emergent fraud aminopyrine in herbal tea. 2023. Food Chemistry, 406, 135065-135073
6、Sha Chen#, Tian Guan#, Zhenjie Qian, Qiqi Quan, JinWang, Xiangmei Li, ShaozongWu, YiyongYan, Xiaojun Yao, Shiwei Zhang, Hongtao Lei*. A sensitive and quantitative immunochromatographic assay for simultaneous detection of three stimulant laxatives in slimming food. 2023. Food Chemistry, 398, 133861-133870
7、 Runlin Shen#, Tian Guan#, Zhaodong Li, Ziling Hong, Boris B Dzantiev, Anatoly V Zherdev, Anastasios Koidis, Xiaojun Yao*, Hongtao Lei*. 2023. Identifying an emergent adulterant hydrochlorothiazide in food: a simple lateral flow strip with high sensitivity by time-resolved fluorescence. Food Control, 143, 109265-109274
8、 Tian Guan, Yudong Shen, Zhuo Jiang, Jin Wan, Shiwei Zhang, Anastasios Koidis, Xiaojun Yao, Yiyong Yan, Hongtao Lei*. Facile fabrication of highly quantum Dot/AuNP-Loaded tags for a dual-Modal colorimetric/reversed ratiometric fluorescence immunochromatographic assay. 2022. Analytical Chemistry, 94, 13463−13472
9、Tian Guan, Yudong Shen, Zhuo Jiang, Yingju Liu, Qileng Aori, Anastasios Koidis, XiaojunYao, Hongtao Lei*、One-step self-assembling multiple hydrophobic quantum dots and hydrophilic biomolecules into all-inclusive tags for ultrasensitive immunosensors. 2022. Sensors and Actuators: B. Chemical, 373, 132720-132729
10. Xuan Zhang, Jin Wang, Jianhao Liang, Zhiwei Liu, Xing Shen, Yingju Liu, Xiangmei Li, Zhenlin Xu, Yi Lei, Hongtao Lei*. 2022. A novel self-aggregated gold nanoparticles based on sensitive immunochromatographic assays for highly detection of opium poppy in herbal teas. Food Chemistry, 390: 133188-133195
11. Peng Zhong#, Xiaoqun Wei#, Xiangmei Li, Xiaoyi Wei, Shaozong Wu, Weijuan Huang, Anastasios Koidis, Zhenlin Xu, Hongtao Lei*、2022. Untargeted metabolomics by liquid chromatography-mass spectrometry for food authentication: A review. Comprehensive Reviews in Food Science and Food Safety, 1–40
12. Tian Guan, Zhenlin Xu, Jin Wang, Yingju Liu, Xing Shen, Xiangmei Li, Yuanming Sun, Hongtao Lei*. Multiplex optical bioassays for food safety analysis: Toward on-site detection. 2022. Comprehensive Reviews in Food Science and Food Safety, 21(2): 1627-1656
13. Jin Wang, Wei Lai, Zhaodong Li, Tian Guan, Yi Lei, Anastasios Koidis, Xing Shen, Xiangmei Li, Xiaojun Yao, Xinan Huang, Hongtao Lei*. 2022. One-step ultra-sensitive immunochromatographic strip authenticating an emergent fraud acetophenetidin in herbal tea. Food and Chemical Toxicology, 165(3): 113183-113189
14. Tian Guan, Yudong Shen, Zhuo Jiang, Yadong Zhao, Zaoqing Liang, Yingju Liu, Xing Shen, Xiangmei Li, ZhenlinXu, Hongtao Lei*. An ultrasensitive microfluidic chip-based immunoassay for multiplex determination of 11 PDE-5 inhibitors in adulterated health foods. 2022. Sensors and Actuators B: Chemical, 358(5): 131450-131458
15. Zhaodong Li#, Haihuan Xie#, Tingdan Fu, Yingying Li, Xing Shen, Xiangmei Li, Yi Lei, Xiaojun Yao, Anastasios Koidis, Yingju Liu, Xinan Huang, Hongtao Lei*. Complementary Strategy Enhancing Broad-Specifificity for Multiplexed Immunoassay of Adulterant Sulfonylureas in Functional Food. 2022. Biosensors, 12, 591-602
16. Tian Guan, Zhuo Jiang, Zaoqing Liang, Yingju Liu, Weijuan Huang, Xiangmei Li, Xing Shen, Mengting Li, Zhenlin Xu, Hongtao Lei*. Single-emission dual-enzyme magnetosensor for multiplex immunofluorometric assay of adulterated colorants in chili seasoning. 2022. Food Chemistry, 366(1): 130594 - 130602
17. Bo Chen, Xing Shen, Zhaodong Li, Jin Wang, Xiangmei Li, Zhenlin Xu, Yudong Shen, Yi Lei, Xinan Huang, Xu Wang, Hongtao Lei*. Antibody Generation and Rapid Immunochromatography Using Time-Resolved Fluorescence Microspheres for Propiconazole: Fungicide Abused as Growth Regulator in Vegetable. 2022. Foods, 11(3): 324-338
18. Lanteng Wang, Jin Wang, Ang Zhang, Xin-an Huang, Hongtao Lei*. Two binding epitopes modulating specificity of immunoassay for β-agonist detection: Quantitative structure-activity relationship. 2021. Food Chemistry, 371(5): 131071- 131081
19. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei*. Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea. 2021. Food Chemistry, 371(5): 131055-131063
20. Peng Zhong, Xiaoqun Wei, Yi Xu, Lulu Zhang, Anastasios Koidis, Yunle Liu, Yi Lei, Shaozong Wu, Hongtao Lei*. Integration of Untargeted and Pseudotargeted Metabolomics for Authentication of Three Shrimp Species Using UHPLC-Q-Orbitrap. 2021. Journal of Agricultural and Food Chemistry, 69(31): 8861–8873
21. Xiaoting Yu, Xu Zhang, Jingjing Xu, Pengyan Guo, Xiangmei Li, Hong Wang, Zhenlin Xu, Hongtao Lei*, Xing Shen*. Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters. 2021. Journal of Hazardous Materials, 418, 126305-12313
22. Gang Zhao, Xing Shen, Yunle Liu, Peichun Xie, Chanyu Yao, Xiangmei Li,Yuanming Sun, Yi Lei, Hongtao Lei*. Direct lysis-multiplex polymerase chain reaction assay for beef fraud substitution with chicken, pork and duck. 2021. Food Control, 129: 108252-108258
23. Yi Xu, Peng Zhong, Aimin Jiang*, Xing Shen, Xiangmei Li, Zhenlin Xu, Yudong Shen, Yuanming Sun, Hongtao Lei*. Raman spectroscopy coupled with chemometrics for food authentication: A review. 2020. Trends in Analytical Chemistry. 131, 116017-116029
24. Ning Lu, Li Ling, Tian Guan, Lanteng Wang, Dian Wang, Jiahui Zhou, Ting Ruan, Xing Shen, Xiangmei Li, Yuanming Sun, Hongtao Lei*. Broad-specificity ELISA with a heterogeneous strategy for sensitive detection of microcystins and nodularin. 2020. Toxicon. 175(2), 44-48
25. Tian Guan, Jianfei He, Dayu Liu, Zaoqing Liang, Bowen Shu, Yiping Chen, Yingju Liu, Xing Shen, Xiangmei Li, Yuanming Sun, Hongtao Lei*. Open surface droplet microfluidic magnetosensor for microcystin-LR monitoring in reservoir. 2020. Analytical Chemistry,92(4), 3409-3416
26. Xiangmei Li, Xinze Wu, Jin Wang, Qicheng Hua, Jinxiao Wu, Xing Shen, Yuanming Sun, Hongtao Lei*. Three lateral flow immunochromatographic assays based on different nanoparticle probes for on-site detection of tylosin and tilmicosin in milk and pork. 2019. Sensors and Actuators B: Chemical. 301(12), 127059–127068
27. Tian Guan, Wenzheng Huang, Ningxia Xu, Zhenzhen Xu, Lelun Jiang, Mengting Li, Xiaoqun Wei, Yingju Liu, Xing Shen, Xiangmei Li, Changqing Yi*, Hongtao Lei*. Point-of-need detection of microcystin-LR using a smartphone-controlled electrochemical analyzer. 2019. Sensors and Actuators B: Chemical. 294,132-140
28. Xiangmei Li, Jin Wang, Changqing Yi, Lelun Jiang, Jinxiao Wu, Xiaomin Chen, Xing Shen, Hongtao Lei*. A smartphone-based quantitative detection device integrated with latex microsphere immunochromatography for on-site detection of zearalenone in cereals and feed. 2019. Sensors and Actuators B: Chemical. 290(1), 170–179
29. Taotao Qiu, Xing Shen, Xiangmei Li, Yunyun Gong, Zhongmin Zou, Chunhong Liu, Feng Ye, Chenyang Mi, Zhenlin Xu, Yuanming Sun, Jie Lin, Huidong Zhang, Hongtao Lei*. Egg Yolk Immunoglobulin supplementation prevents rat liver from Aflatoxin B1-induced oxidative damage and genotoxicity. 2018. Journal of Agricultural and Food Chemistry, 66(50),13260-13267
30、Lanteng Wang,Wenmeng Jiang, Xing Shen, Xiangmei Li, Xinan Huang, Zhenlin Xu, Yuanming Sun, Shun-Wan Chan, Lingwen Zeng, Sergei Alexandrovich Eremin, Hongtao Lei*. Four Hapten Spacer Sites Modulating Class Specificity: Non-directional Multianalyte Immunoassay for 31 β-agonists and Analogues. 2018. Analytical Chemistry, 90(4), 2716–2724
Research Projects
1. Key technology research on multidimensional identification and detection of important food authenticity, leading a key research and development project with a funding of 29.57 million yuan.
2. Leading the research, development, and demonstration application of visual rapid detection technology for important Marine biotoxins as part of the General project of Marine Economic Development of Guangdong Province (Special project of six Marine Industries) with a funding of 2 million yuan.
3. Leading the enhancement of research on natural umami substances and precise control technology for Guangdong-style high-salt dilute soy sauce as part of the 2022 project in Yangjiang City with a funding of 1 million yuan.
4. Hosting a study on enantioselective perturbation effect of chiral pesticide isopropachlor on intestinal flora funded by RMB 100,000 from the Natural Science Foundation of Guangdong Province.
5. Hosting a research project on the broad-spectrum specific structural basis and targeted regulation of microcystin antibodies funded by 600,000 yuan from the National Natural Science Foundation of China.
6. Hosting the construction project for Heyuan Modern Agriculture Comprehensive Experimental Station (Platform) in Guangdong-Hong Kong-Macao Greater Bay Area with a funding amounting to 2.5 million yuan.
7. Hosting the full cycle composition determination and functional analysis project for Prickly pear and Gleditsia sinensis funded by 2 million yuan from Rural Agriculture Department Project in Guangdong Province.
8. Leading the construction team for agricultural product quality and safety common key technology innovation under Guangdong Province modern agricultural industry common key technology research and development innovation team project with a funding amounting to 2 million yuan.
9. Hosting an investigation into molecular recognition basis algal toxin multi-target broad-spectrum specific immunoassay supported by Key Project funds totaling to 2.6 million yuan from National Natural Science Foundation of China
10. Leading an exploration into molecular recognition mechanism hapten-antibody chemical pollutants under support from funds totaling to RMB two Million Yuan provided through The Team Project of The Guandong Natural Science Foundation.
